About Advair

ADVAIR for Asthma

Is There More You Can Do That May Help Prevent Your Asthma Symptoms?

ADVAIR treats two of the main causes of asthma symptoms—airway constriction and airway inflammation—to help prevent symptoms in the first place. Results may vary. ADVAIR is not used to relieve sudden breathing problems and won't replace a rescue inhaler.

If you are on a long-term asthma control medicine, such as an inhaled corticosteroid, and your symptoms keep coming back, talk to your doctor and find out if ADVAIR may be right for you.

ADVAIR should be used only if your doctor decides that your asthma is not well controlled with a long-term asthma control medicine, such as an inhaled corticosteroid. Once your asthma is well controlled, your doctor will decide if you can stop ADVAIR and may prescribe a different asthma control medicine, like an inhaled corticosteroid.

ADVAIR DISKUS 250/50 for COPD

ADVAIR DISKUS 250/50 Is Clinically Proven to Help Significantly Improve Lung Function.*

Your Results May Vary.

ADVAIR DISKUS 250/50 helps significantly improve lung function* so you can breathe better and is clinically proven to help reduce the number of COPD exacerbations in people who have had an exacerbation. Your results may vary. An exacerbation is when your COPD symptoms (including cough, increased mucus production, and shortness of breath) are worse than usual. This can last for a few days or longer and often requires treatment with antibiotics, oral steroids, and, in some cases, hospitalization.

ADVAIR DISKUS contains both an anti-inflammatory medicine (fluticasone propionate†) and a long-acting bronchodilator (salmeterol) working together to help improve your lung function.

COPD is a chronic condition that is always there. That's why it is important to take ADVAIR DISKUS twice a day, every day, to help improve lung function so you can breathe better.* Your results may vary. ADVAIR DISKUS is approved for adults with COPD, including chronic bronchitis, emphysema, or both. ADVAIR DISKUS is not for, and should not be used to treat, sudden symptoms of COPD. ADVAIR DISKUS won't replace a rescue inhaler. You should only take 1 inhalation of ADVAIR DISKUS twice a day. Higher doses will not provide additional benefits.

Ask your doctor if ADVAIR DISKUS is right for you.

ADVAIR HFA is not approved for the treatment of COPD.

  • *Measured by a breathing test in people taking ADVAIR DISKUS 250/50, compared with people taking either fluticasone propionate 250 mcg, salmeterol 50 mcg, or placebo.
  • †It is not known how anti-inflammatory medicines work in COPD.

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IMPORTANT SAFETY INFORMATION

People with asthma who take long-acting beta2-adrenergic agonist (LABA) medicines, such as salmeterol (one of the medicines in ADVAIR), have an increased risk of death from asthma problems. It is not known if LABA medicines increase the risk of death in people with COPD.

Important Safety Information

  • People with asthma who take long-acting beta2-adrenergic agonist (LABA) medicines, such as salmeterol (one of the medicines in ADVAIR), have an increased risk of death from asthma problems. It is not known whether fluticasone propionate, the other medicine in ADVAIR, reduces the risk of death from asthma problems seen with LABA medicines, such as salmeterol.
  • It is not known if LABA medicines, such as salmeterol, increase the risk of death in people with COPD.
  • Call your healthcare provider if breathing problems worsen over time while using ADVAIR. You may need different treatment.
  • Get emergency medical care if:
    • your breathing problems worsen quickly
    • you use your rescue inhaler, but it does not relieve your breathing problems
  • ADVAIR should be used only if your healthcare provider decides that your asthma is not well controlled with a long-term asthma control medicine, such as an inhaled corticosteroid.
  • When your asthma is well controlled, your healthcare provider may tell you to stop taking ADVAIR. Your healthcare provider will decide if you can stop ADVAIR without loss of asthma control. Your healthcare provider may prescribe a different asthma control medicine for you, such as an inhaled corticosteroid.
  • Children and adolescents with asthma who take LABA medicines may have an increased risk of hospitalization for asthma problems.
  • Do not use ADVAIR to treat sudden breathing problems from asthma or COPD. Always have a rescue inhaler with you to treat sudden symptoms.
  • Do not use ADVAIR DISKUS if you have a severe allergy to milk proteins. Do not use ADVAIR DISKUS or ADVAIR HFA if you are allergic to any of the ingredients in the products. Ask your healthcare provider if you are not sure.
  • Do not use ADVAIR more often than prescribed.
  • Do not take ADVAIR with other medicines that contain a LABA for any reason.
  • Tell your healthcare provider about all the medicines you take and about all of your health conditions.
  • ADVAIR can cause serious side effects, including:
    • fungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using ADVAIR to help reduce your chance of getting thrush.
    • pneumonia. People with COPD have a higher chance of getting pneumonia. ADVAIR DISKUS may increase the chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms:
      • increase in mucus (sputum) production
      • change in mucus color
      • fever
      • chills
      • increased cough
      • increased breathing problems
    • weakened immune system and increased chance of getting infections (immunosuppression). You should avoid exposure to chickenpox and measles, and, if exposed, tell your healthcare provider right away. Worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or herpes infection of the eye (ocular herpes simplex) may occur.
    • reduced adrenal function. This can happen when you stop taking an oral corticosteroid (such as prednisone) and start taking a medicine containing an inhaled corticosteroid (such as ADVAIR). During this transition period, when your body is under stress such as from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death. Symptoms of adrenal insufficiency include:
      • feeling tired
      • lack of energy
      • weakness
      • nausea and vomiting
      • low blood pressure
    • sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop using ADVAIR DISKUS and call your healthcare provider right away.
    • serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
      • rash
      • hives
      • swelling of your face, mouth, and tongue
      • breathing problems
    • effects on heart
      • increased blood pressure
      • a fast or irregular heartbeat
      • chest pain
    • effects on nervous system
      • tremor
      • nervousness
    • bone thinning or weakness (osteoporosis)
    • slowed growth in children. A child's growth should be checked often.
    • eye problems including glaucoma and cataracts. You should have regular eye exams while using ADVAIR.
    • changes in laboratory blood values (sugar, potassium, certain types of white blood cells)
  • Common side effects of ADVAIR DISKUS for asthma include:
    • upper respiratory tract infection
    • throat irritation
    • hoarseness and voice changes
    • thrush in your mouth or throat
    • bronchitis
    • cough
    • headache
    • nausea and vomiting
    • In children with asthma, infections in the ear, nose, and throat are common.
  • Common side effects of ADVAIR DISKUS 250/50 for COPD include:
    • thrush in your mouth or throat
    • throat irritation
    • hoarseness and voice changes
    • viral respiratory infections
    • headache
    • muscle and bone pain
  • Common side effects of ADVAIR HFA for asthma include:
    • upper respiratory tract infection
    • throat irritation
    • hoarseness and voice changes
    • headache
    • dizziness
    • nausea and vomiting
  • Rinse your mouth with water without swallowing after using ADVAIR to help reduce your chance of getting thrush.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

ADVAIR, ADVAIR DISKUS, DISKUS and the shape of the DISKUS inhaler are registered trademarks of the GSK group of companies.

The color PURPLE used with inhalers for ADVAIR is a trademark of the GSK group of companies.