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COPD Q&A
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ADVAIR DISKUS 250/50 is excited to bring you an insightful Q&A discussion with COPD specialist Dr. Katharine Knobil.

Q&A with Dr. Katharine Knobil
Katharine Knobil, MD, is Vice President of Global Clinical Development, Respiratory, at GlaxoSmithKline. Dr. Knobil is board-certified in Internal Medicine and Pulmonary Disease. She is a member of the American Thoracic Society, the Drug Information Association, and the American Academy of Pharmaceutical Physicians.

What is COPD?

Dr. Knobil:

COPD stands for chronic obstructive pulmonary disease. It's a term for a condition in which the airflow into and out of the lungs is reduced due to chronic bronchitis or emphysema, or a combination of both. Patients may experience symptoms of one or more of these conditions.

What is chronic bronchitis?

Dr. Knobil:

Chronic bronchitis occurs when the lining of the bronchial tubes becomes inflamed and produces excess mucus that clogs the airways. While many people will suffer a brief episode of acute bronchitis with coughing and spitting, chronic bronchitis occurs when a mucus-producing cough lasts for months, even years.

What is emphysema?

Dr. Knobil:

Emphysema is caused by the weakening and breaking down of the air sacs at the end of the bronchial tubes. These changes are permanent, and the lungs no longer work as well as they should. Many patients with emphysema also have chronic bronchitis.

Why can't people with COPD seem to catch their breath?

Dr. Knobil:

When affected areas of the lung become enlarged, they trap "stale" air and don't effectively exchange it with fresh air, causing shortness of breath. Over time the lungs can become badly damaged, leaving fewer functioning areas where air can be exchanged.

What can be done for COPD?

Dr. Knobil:

If you still smoke, the first thing to do is stop. Even if you already have COPD, quitting smoking can help prevent further lung damage. There are also medications available that can help people with COPD breathe better. Talk to your doctor to see if you are doing all you can for your condition.

Is smoking the main cause of COPD?

Dr. Knobil:

Smoking is responsible for the vast majority of COPD cases. Cigarette smoke can induce inflammation and directly damage the lungs. It is believed that this inflammation can then lead to COPD.

Smoking cessation is the single most effective—and cost-effective—intervention to reduce the risk of developing COPD.

How can people with COPD live more comfortably with their condition?

Dr. Knobil:

Healthcare professionals can help people with COPD live more comfortably with their disease. The healthcare professional's advice and treatment may include: quitting smoking, medications, supplemental oxygen, exercise, antibiotics, and vaccines.

Does exercise help patients with COPD?

Dr. Knobil:

It's true. Believe it or not, even a mild to moderate workout routine can improve your health. In fact, physical activity has many benefits for the person with COPD. It improves muscle tone, increases energy level, strengthens the heart, and gives you a more positive outlook. Exercise also improves cardiovascular efficiency, which helps you to do more with less effort. Your healthcare professional will tell you how much exercise you should do, and how much is too much.

My doctor instructed me to perform breathing exercises. Do these really work?

Dr. Knobil:

Breathing exercises can help strengthen the muscles used in breathing as part of a pulmonary rehabilitation program to condition the rest of the body.

Are there diet tips for people with COPD?

Dr. Knobil:

Use salt in moderation. Too much sodium can cause you to retain fluids, which can interfere with your breathing. Also, snack healthfully. Prepackaged snack foods like potato chips and cookies typically contain large amounts of salt, fat, and sugar; they also usually have little in the way of nutrients. It's best to eat fresh, healthy foods. Healthy snacks also help keep up your energy. Finally, drink lots of fluids, unless you are told not to by a healthcare professional. Go light on the soft drinks; fruit juices are better choices, and water is best of all. Keeping your body hydrated may help loosen phlegm, mucus, or sputum so that they can be more easily dislodged by coughing.

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Important information about ADVAIR DISKUS 250/50
ADVAIR DISKUS 250/50 is approved for adults with COPD, including chronic bronchitis, emphysema, or both. You should only take 1 inhalation of ADVAIR twice a day. Higher doses will not provide additional benefits. People with COPD taking ADVAIR may have a higher chance of pneumonia. Call your doctor if you notice any of the following symptoms: change in amount or color of sputum, fever, chills, increased cough, or increased breathing problems. ADVAIR may increase your risk of osteoporosis and some eye problems (cataracts or glaucoma). You should have regular eye exams. Thrush in the mouth and throat may occur. Tell your doctor if you have a heart condition or high blood pressure before taking ADVAIR. Do not use ADVAIR with long-acting beta2-agonists for any reason. ADVAIR does not replace fast-acting inhalers for sudden symptoms.

Complete Prescribing Information and Medication Guide for ADVAIR DISKUS® (fluticasone propionate and salmeterol inhalation powder).

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