ADVAIR DISKUS is clinically proven to help significantly improve
lung function.*

If you are an adult living with chronic obstructive pulmonary
disease (COPD), including chronic bronchitis, emphysema,
or both, you may find that your breathing has become difficult.
ADVAIR helps significantly improve lung function so you can
breathe better. Your results may vary. Unlike most COPD
medications, ADVAIR contains both an anti-inflammatory^† and
a long-acting bronchodilator working together to help improve
your lung function.

ADVAIR DISKUS is not for, and should not be used to treat, sudden, severe symptoms of COPD. ADVAIR won't replace a rescue inhaler. You should only take 1 inhalation of ADVAIR twice a day. Higher doses will not provide additional benefits. Talk to your doctor to see if prescription ADVAIR DISKUS is right for you.

*Measured by a breathing test in people taking ADVAIR DISKUS 250/50, compared with people taking either fluticasone propionate 250 mcg or salmeterol 50 mcg. Your results may vary.

†It is not known how anti-inflammatories work in COPD.

Important Safety Information About ADVAIR DISKUS^® 250/50 (fluticasone propionate 250 mcg and salmeterol 50 mcg inhalation powder)

• Do not use ADVAIR to treat sudden, severe symptoms of asthma or COPD. Always have a rescue inhaler medicine with you to treat sudden symptoms.
• Do not use ADVAIR DISKUS if you have severe allergy to milk proteins. Ask your doctor if you are not sure.
• Do not use ADVAIR more often than prescribed. Do not take ADVAIR with other medicines that contain long-acting beta₂-agonists for any reason. Tell your doctor about medicines you take and about all of your medical conditions.
• ADVAIR DISKUS can cause serious side effects, including:
  • serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    • rash
    • hives
    • swelling of the face, mouth, and tongue
    • breathing problems
  • sudden breathing problems immediately after inhaling your medicine
  • effects on heart
    • increased blood pressure
    • a fast and irregular heartbeat
    • chest pain
  • effects on nervous system
    • tremor
    • nervousness
  • reduced adrenal function (may result in loss of energy)
  • changes in blood (sugar, potassium, certain types of white blood cells)
  • weakened immune system and a higher chance of infections. You should avoid exposure to chickenpox and measles, and, if exposed, consult your healthcare provider without delay. Worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or ocular herpes simplex may occur.
  • lower bone mineral density. This may be a problem for people who already have a higher chance of low bone density (osteoporosis).
  • eye problems including glaucoma and cataracts. You should have regular eye exams while using ADVAIR.
  • pneumonia. People with COPD have a higher chance of getting pneumonia. ADVAIR may increase the chance of getting pneumonia. Call your doctor if you notice any of the following symptoms:
    • increase in mucus (sputum) production
    • change in mucus color
    • fever
    • chills
    • increased cough
    • increased breathing problems
• Common side effects of ADVAIR DISKUS 250/50 for COPD include:
  • thrush in the mouth and throat
  • throat irritation
  • hoarseness and voice changes
  • viral respiratory infections
  • headache
  • muscle and bone pain
    

Complete Prescribing Information and Medication Guide for ADVAIR DISKUS