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We'd like to help you use ADVAIR DISKUS correctly. Review the instructions below for using ADVAIR DISKUS, and if you have any questions, ask your healthcare provider or pharmacist. This presentation is intended to complement the Medication Guide for ADVAIR DISKUS. For full instructions on how to use ADVAIR DISKUS, and other important information, please see the complete Prescribing Information, including Boxed Warning and Medication Guide, for ADVAIR DISKUS.

Sliding the lever
(until it clicks) prepares
the dose to be inhaled
Protects the mouthpiece
when not in use
Where to place your
mouth to inhale the
Where to place your
thumb while opening
and closing the DISKUS
Keeps track of how many
doses you have left

Follow these instructions for using your ADVAIR DISKUS®.

  • You will breathe in (inhale) the medicine from the DISKUS®.
  • If you have any questions, ask your healthcare provider or pharmacist.

Take ADVAIR DISKUS out of the box and foil pouch. Write the "Pouch opened" and "Use by" dates on the label on top of the DISKUS®. The "Use by" date is 1 month from date of opening the pouch.

The DISKUS will be in the closed position when the pouch is opened.

The dose indicator on the top of the DISKUS tells you how many doses are left. The dose indicator number will decrease each time you use the DISKUS.

After you have used 55 doses from the DISKUS, the numbers 5 to 0 will appear in red to warn you that there are only a few doses left.

If you are using a "sample" DISKUS, the numbers 5 to 0 will appear in red after 9 doses.

Taking a dose from the DISKUS requires the
following 3 simple steps: OPEN, CLICK, INHALE.


Hold the DISKUS in one hand and put the thumb of your other hand on the thumbgrip.


Push your thumb away from you as far as it will go until the mouthpiece appears and snaps into position.


Hold the DISKUS in a level, flat position with the mouthpiece towards you.


Slide the lever away from you as far as it will go until it clicks. The DISKUS is now ready to use.

Every time the lever is pushed back, a dose is ready to be inhaled. This is shown by a decrease in numbers on the dose counter.

To avoid releasing or wasting doses once the DISKUS is ready:

  • Do not close the DISKUS.
  • Do not tilt the DISKUS.
  • Do not play with the lever.
  • Do not move the lever more than once.


Before inhaling your dose from the DISKUS, breathe out (exhale) fully while holding the DISKUS level and away from your mouth. Remember, never breathe out into the DISKUS mouthpiece.


Put the mouthpiece to your lips. Breathe in quickly and deeply through the DISKUS. Do not breathe in through your nose.


Remove the DISKUS from your mouth. Hold your breath for about 10 seconds, or for as long as is comfortable.


Breathe out slowly.

The DISKUS delivers your dose of medicine as a very fine powder. You may or may not taste or feel the powder. Do not use an extra dose from the DISKUS if you do not feel or taste the medicine.

Rinse your mouth with water after breathing-in the medicine.

Spit the water out. Do not swallow.


Close the DISKUS when you are finished taking a dose so that the DISKUS will be ready for you to take your next dose. Put your thumb on the thumbgrip and slide the thumbgrip back towards you as far as it will go.

4: CLOSE (continued)

The DISKUS will click shut. The lever will automatically return to its original position.

The DISKUS is now ready for you to take your next scheduled dose, due in about 12 hours. (Repeat steps 1 to 4.)

  • Store ADVAIR DISKUS at room temperature between 68°F to 77°F (20°C to 25°C). Keep in a dry place away from heat and sunlight.
  • Safely discard ADVAIR DISKUS 1 month after you remove it from the foil pouch, or after the dose indicator reads "0", whichever comes first.
  • Keep ADVAIR DISKUS and all medicines out of the reach of children.
  • Never breathe into the DISKUS.
  • Never take the DISKUS apart.
  • Always ready and use the DISKUS in a level, flat position.
  • Do not use the DISKUS with a spacer device.
  • After each dose, rinse your mouth with water and spit the water out. Do not swallow.
  • Never wash the mouthpiece or any part of the DISKUS. Keep it dry.
  • Always keep the DISKUS in a dry place.
  • Never take an extra dose, even if you did not taste or feel the medicine.

Approved Uses for ADVAIR DISKUS 250/50 for COPD

ADVAIR DISKUS 250/50 is approved for adults with chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both. ADVAIR DISKUS is not for, and should not be used to treat, sudden, severe symptoms of COPD. ADVAIR DISKUS won’t replace a rescue inhaler. You should only take 1 inhalation of ADVAIR DISKUS twice a day. Higher doses will not provide additional benefits.

Important Safety Information for ADVAIR DISKUS® 250/50 (fluticasone propionate 250 mcg and salmeterol 50 mcg inhalation powder)

  • People with asthma who take long-acting beta2-adrenergic agonist (LABA) medicines, such as salmeterol (one of the medicines in ADVAIR DISKUS), have an increased risk of death from asthma problems. It is not known whether fluticasone propionate, the other medicine in ADVAIR DISKUS, reduces the risk of death from asthma problems seen with salmeterol.
    • Call your healthcare provider if breathing problems worsen over time while using ADVAIR DISKUS. You may need different treatment.
    • Get emergency medical care if:
      • breathing problems worsen quickly and
      • you use your rescue inhaler medicine, but it does not relieve your breathing problems.
  • Do not use ADVAIR DISKUS to treat sudden, severe symptoms of asthma or COPD. Always have a rescue inhaler medicine with you to treat sudden symptoms.
  • Do not use ADVAIR DISKUS if you have a severe allergy to milk proteins. Ask your doctor if you are not sure.
  • Do not use ADVAIR DISKUS more often than prescribed. Do not take ADVAIR DISKUS with other medicines that contain long-acting beta2-agonists for any reason. Tell your doctor about medicines you take and about all of your medical conditions.
  • ADVAIR DISKUS can cause serious side effects, including:
    • serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
      • rash
      • hives
      • swelling of the face, mouth, and tongue
      • breathing problems
    • sudden breathing problems immediately after inhaling your medicine
    • effects on heart
      • increased blood pressure
      • a fast and irregular heartbeat
      • chest pain
    • effects on nervous system
      • tremor
      • nervousness
    • reduced adrenal function (may result in loss of energy)
    • changes in blood (sugar, potassium, certain types of white blood cells)
    • weakened immune system and a higher chance of infections. You should avoid exposure to chickenpox and measles, and, if exposed, consult your healthcare provider without delay. Worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or ocular herpes simplex may occur.
    • lower bone mineral density. This may be a problem for people who already have a higher chance of low bone density (osteoporosis).
    • eye problems including glaucoma and cataracts. You should have regular eye exams while using ADVAIR DISKUS.
    • pneumonia. People with COPD have a higher chance of getting pneumonia. ADVAIR DISKUS may increase the chance of getting pneumonia. Call your doctor if you notice any of the following symptoms:
      • increase in mucus (sputum) production
      • change in mucus color
      • fever
      • chills
      • increased cough
      • increased breathing problems
    • Common side effects of ADVAIR DISKUS 250/50 for COPD include:
      • thrush in the mouth and throat
      • throat irritation
      • hoarseness and voice changes
      • viral respiratory infections
      • headache
      • muscle and bone pain
    • After each dose, rinse your mouth with water and spit the water out. Do not swallow.

    Complete Prescribing Information, including Boxed Warning and Medication Guide, for ADVAIR DISKUS

ADVAIR DISKUS 250/50 for COPD|Learn About ADVAIR®|Risks & Side Effects|If You Are Taking ADVAIR
Coupons & Offers for ADVAIR|What Is COPD?|Living With COPD
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